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Table 1 The genetic loci associated with psoriasis identified by GWAS

From: The immunological and genetic aspects in psoriasis

Chromosomal Reported gene(s) SNP Context P value Odds ratio (95% CI) Population Ref.
1q21.3 LCE3B, LCE3D rs6677595 Intergenic 2.1 × 10−33 1.26 [NR] European (Tsoi et al. [2012])
LCE3D, LCE3A rs4085613 Intergenic 7 × 10−30 1.32 [1.25 to 1.39] Chinese (Zhang et al. [2009])
LCE3D rs4112788 Intergenic 3 × 10−10 1.29 [1.19 to 1.40] European (Strange et al. [2010])
1p36.23 SLC45A1, TNFRSF9 rs11121129 Intergenic 1.7 × 10−8 1.13 [NR] European (Tsoi et al. [2012])
1p36.11 RUNX3 rs7536201 nearGene-5 2.3 × 10−12 1.13 [NR] European
IL28RA rs7552167 Intergenic 8.5 × 10−12 1.21 [NR] European
rs4649203 Intergenic 7 × 10−8 1.13 [1.05 to 1.22] European (Strange et al. [2010])
3.91 × 10−12 1.16 [NR] Chinese (Cheng et al. [2013])
1p31.3 IL23R rs2201841 Intron 1.75× 10−10 1.23 [NR] European (Elder [2009])
rs9988642 nearGene-3 1.1 × 10−26 1.52 [NR] European (Tsoi et al. [2012])
rs11209026 Missense 7 × 10−7 1.49 [1.27 to 1.74] European (Strange et al. [2010])
rs2201841 Intron 3 × 10−8 1.13 [NR] European (Nair et al. [2009])
2q24.3 IFIH1 rs17716942 Intron 1 × 10−13 1.29 [1.17 to 1.43] European (Strange et al. [2010])
2p16.1 FLJ16341, REL rs62149416 Intergenic 1.8 × 10−17 1.17 [NR] European (Tsoi et al. [2012])
REL rs702873 Intron 4 × 10−9 1.12 [1.04 to 1.20] European (Strange et al. [2010])
NR rs842636 Intron 6 × 10−6 1.15 [NR] European (Stuart et al. [2010])
2p15 B3GNT2 rs10865331 Intergenic 4.7 × 10−10 1.12 [NR] European (Tsoi et al. [2012])
5q33.3 PTTG1 rs2431697 Intergenic 1.11 × 10−8 1.20 [1.13 to 1.28] Chinese (Sun et al. [2010])
IL12B rs12188300 Intergenic 3.2 × 10−53 1.58 [NR] European (Tsoi et al. [2012])
rs2546890 ncRNA 1 × 10−20 1.54 [1.32 to 1.79] European (Ellinghaus et al. [2010])
rs3213094 Intron 5 × 10−11 1.39 [1.26 to 1.53] European (Strange et al. [2010])
rs2082412 Intergenic 2 × 10−28 1.44 [NR] European (Nair et al. [2009])
rs3213094 Intron 3 × 10−26 1.28 [1.23 to 1.35] Chinese (Zhang et al. [2009])
rs2082412 Intergenic 4.75× 10−18 1.42 [NR] European (Elder [2009])
5q33.1 TNIP1/ANXA6 rs3762999 Intergenic 4.55 × 10−18 1.23 [1.18 to 1.29] Chinese (Sun et al. [2010])
rs999556 Intergenic 3.83 × 10−21 1.25 [1.20 to 1.31] Chinese
TNIP1 rs17728338 Intergenic 1.4× 10−13 1.56 [NR] European (Elder [2009])
rs2233278 UTR-5 2.2 × 10−42 1.59 [NR] European (Tsoi et al. [2012])
rs17728338 Intergenic 1 × 10−20 1.59 [NR] European (Nair et al. [2009])
IL13, IL4 rs1295685 Intergenic 3.4 × 10−10 1.18 [NR] European (Tsoi et al. [2012])
IL13 rs20541 Missense 5 × 10−15 1.27 [NR] European (Nair et al. [2009])
5q15 ERAP1 rs27432 Intron 1.9 × 10−20 1.2 [NR] European (Tsoi et al. [2012])
rs27524 Intron 3 × 10−11 1.13 [1.05 to 1.22] European (Strange et al. [2010])
rs151823 Intergenic 9.32 × 10−9 0.89 [0.85 to 0.92] Chinese (Sun et al. [2010])
5q15 LNPEP rs2303138 Missense 1.83 × 10−13 1.16 [NR] Chinese (Cheng et al. [2013])
6q25.4 EXOC2, IRF4 rs9504361 Intergenic 2.1 × 10−11 1.12 [NR] European (Tsoi et al. [2012])
6q25.3 TAGAP rs2451258 Intergenic 3.4 × 10−8 1.12 [NR] European
6q23.3 TNFAIP3 rs610604 Intron 3.07× 10−10 1.23 [NR] European (Elder [2009])
   rs582757 Intron 2.2 × 10−25 1.23 [NR] European (Tsoi et al. [2012])
   rs610604 Intron 9 × 10−12 1.19 [NR] European (Nair et al. [2009])
6q21 TRAF3IP2 rs33980500 Missense 4.2 × 10−45 1.52 [NR] European (Tsoi et al. [2012])
rs458017 Missense 2 × 10−16 1.37 [1.22 to 1.54] European (Strange et al. [2010])
rs13196377 Intron 1.39 × 10−12 1.67 [1.45 to 1.93] European (Huffmeier et al. [2010])
rs13190932 Intron 8.56 × 10−17 1.83 [1.59 to 2.12] European
rs13210247 Missense 1.73 × 10−14 1.69 [1.48 to 1.94] European
rs33980500 Missense 1 × 10−16 NR European (Ellinghaus et al. [2010])
rs240993 Intron 5 × 10−20 1.25 [1.16 to 1.34] European (Strange et al. [2010])
6p21.33 HLA-C rs1265181 Intergenic 1.93 × 10−208 22.62 [NR] Chinese (Zhang et al. [2009])
rs12191877 Intergenic 2.98× 10−178 2.87 [NR] European (Elder [2009])
rs13191343 Intergenic 2.32 × 10−72 2.37 [2.16 to 2.61] European (Huffmeier et al. [2010])
rs12191877 Intergenic 4 × 10−32 2.79 [2.35 to 3.33] European (Ellinghaus et al. [2010])
rs10484554 Intergenic 4 × 10−214 4.66 [4.23 to 5.13] European (Strange et al. [2010])
rs12191877 Intergenic 1 × 10−100 2.64 [NR] European (Nair et al. [2009])
rs10484554 Intergenic 2 × 10−39 2.8 [2.40 to 3.30] European (Liu et al. [2008])
rs3134792 Intergenic 1 × 10−9 NR European (Capon et al. [2008])
HLA-B, HLA-C rs4406273 Intergenic 4.5 × 10−723 4.32 [NR] European (Tsoi et al. [2012])
HCP5 rs2395029 ncRNA 2 × 10−26 4.1 [3.10 to 5.30] European (Liu et al. [2008])
7p14.1 ELMO1 rs2700987 Intron 4.3 × 10−9 1.11 [NR] European (Tsoi et al. [2012])
8p23.2 CSMD1 rs7007032 Intron 3.78 × 10−8 1.16 [1.10 to 1.22] Chinese (Sun et al. [2010])
rs10088247 Intron 4.54 × 10−9 1.17 [1.11 to 1.23] Chinese
9q34.13 TSC1 rs1076160 Intron 6 × 10−6 1.09 [NR] European (Nair et al. [2009])
9q31.2 KLF4 rs10979182 Intergenic 2.3 × 10−8 1.12 [NR] European (Tsoi et al. [2012])
9p21.1 DDX58 rs11795343 Intron 8.4 × 10−11 1.11 [NR] European
10q22.3 ZMIZ1 rs1250546 Intron 6.8 × 10−7 1.1 [NR] European
11q24.3 ETS1 rs3802826 Intron 9.5 × 10−10 1.12 [NR] European
ZC3H12C rs4561177 nearGene-5 7.7 × 10−13 1.14 [NR] European
11q13.1 RPS6KA4, PRDX5 rs645078 Intergenic 2.2 × 10−6 1.09 [NR] European
12q13.3 STAT2, IL23A rs2066819 Intergenic 5.4 × 10−17 1.39 [NR] European
IL23A, STAT2 rs2066808 Intron 1 × 10−9 1.34 [NR] European (Nair et al. [2009])
IL23A rs2066807 Missense 1.9× 10−5 1.33 [NR] European (Elder [2009])
rs2066808 Intron 2 × 10−7 1.49 [1.28 to 1.73] European (Strange et al. [2010])
12q13.2 RPS26 rs12580100 Intergenic 1 × 10−6 1.17 [NR] European (Stuart et al. [2010])
13q14.11 COG6 rs7993214 Intron 2 × 10−6 1.41 [1.22 to 1.61] European (Liu et al. [2008])
GJB2 rs3751385 UTR-3 8.57 × 10−8 0.87 [0.84 to 0.91] Chinese (Sun et al. [2010])
14q13.2 NFKBIA, PSMA6 rs12586317 Intron 2 × 10−8 1.15 [NR] European (Stuart et al. [2010])
NFKBIA rs8016947 Intergenic 2 × 10−11 1.19 [1.11 to 1.27] European (Strange et al. [2010])
3.9 × 10−10 1.12 [NR] Chinese (Li et al. [2013])
16p13.13 PRM3, SOCS1 rs367569 Intergenic 4.9 × 10−8 1.13 [NR] European (Tsoi et al. [2012])
16p11.2 PRSS53, FBXL19 rs12445568 Intergenic 1.2 × 10−16 1.16 [NR] European
FBXL19, POL3S rs10782001 Intron 9 × 10−10 1.16 [NR] European (Stuart et al. [2010])
17q25.3 CARD14 rs11652075 Missense 3.4 × 10−8 1.11 [NR] European (Tsoi et al. [2012])
17q21.2 PTRF, STAT3, STAT5A/B rs963986 Intergenic 5.3 × 10−9 1.15 [NR] European
17q11.2 NOS2 rs28998802 Intron 3.3 × 10−16 1.22 [NR] European
rs4795067 Intron 4 × 10−11 1.19 [NR] European (Stuart et al. [2010])
NR rs1975974 Intergenic 1 × 10-7 1.17 [NR] European
18q22.1 SERPINB8 rs514315 nearGene-3 5.92 × 10−9 0.87 [0.83 to 0.91] Chinese (Sun et al. [2010])
18q21.2 POL1, STARD6, MBD2 rs545979 Intergenic 3.5 × 10−10 1.12 [NR] European (Tsoi et al. [2012])
19q13.41 ZNF816A rs9304742 Intron 2.11 × 10−9 0.88 [0.84 to 0.92] Chinese (Sun et al. [2010])
19p13.2 ILF3, CARM1 rs892085 Intergenic 3.0 × 10−17 1.17 [NR] European (Tsoi et al. [2012])
TYK2 rs34536443 Missense 9.1 × 10−31 1.88 [NR] European
rs12720356 Missense 4 × 10−11 1.4 [1.23 to 1.61] European (Strange et al. [2010])
rs280519 Intron 4 × 10−9 1.13 [1.05 to 1.21] European
20q13.13 ZNF313 rs2235617 Intron 2 × 10−6 1.2 [1.11 to 1.30] European
RNF114 rs1056198 Intron 1.5 × 10−14 1.16 [NR] European (Tsoi et al. [2012])
ZNF313 rs495337 Cds-synon 1 × 10−8 1.25 [1.12 to 1.39] European (Capon et al. [2008])
20q13.12 SDC4 rs1008953 Intergenic 1 × 10−7 1.14 [NR] European (Stuart et al. [2010])
22q11.21 UBE2L3 rs4821124 Intron 3.8 × 10−8 1.13 [NR] European (Tsoi et al. [2012])
  1. NR, not reported; UTR, untranslated region; ncRNA, noncoding RNA; nearGene-5/3, a SNP close to the 5′ or 3′ end of a gene. Intergenic: a stretch of sequences located between genes.