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Table 1 The genetic loci associated with psoriasis identified by GWAS

From: The immunological and genetic aspects in psoriasis

Chromosomal

Reported gene(s)

SNP

Context

P value

Odds ratio (95% CI)

Population

Ref.

1q21.3

LCE3B, LCE3D

rs6677595

Intergenic

2.1 × 10−33

1.26 [NR]

European

(Tsoi et al. [2012])

LCE3D, LCE3A

rs4085613

Intergenic

7 × 10−30

1.32 [1.25 to 1.39]

Chinese

(Zhang et al. [2009])

LCE3D

rs4112788

Intergenic

3 × 10−10

1.29 [1.19 to 1.40]

European

(Strange et al. [2010])

1p36.23

SLC45A1, TNFRSF9

rs11121129

Intergenic

1.7 × 10−8

1.13 [NR]

European

(Tsoi et al. [2012])

1p36.11

RUNX3

rs7536201

nearGene-5

2.3 × 10−12

1.13 [NR]

European

IL28RA

rs7552167

Intergenic

8.5 × 10−12

1.21 [NR]

European

rs4649203

Intergenic

7 × 10−8

1.13 [1.05 to 1.22]

European

(Strange et al. [2010])

3.91 × 10−12

1.16 [NR]

Chinese

(Cheng et al. [2013])

1p31.3

IL23R

rs2201841

Intron

1.75× 10−10

1.23 [NR]

European

(Elder [2009])

rs9988642

nearGene-3

1.1 × 10−26

1.52 [NR]

European

(Tsoi et al. [2012])

rs11209026

Missense

7 × 10−7

1.49 [1.27 to 1.74]

European

(Strange et al. [2010])

rs2201841

Intron

3 × 10−8

1.13 [NR]

European

(Nair et al. [2009])

2q24.3

IFIH1

rs17716942

Intron

1 × 10−13

1.29 [1.17 to 1.43]

European

(Strange et al. [2010])

2p16.1

FLJ16341, REL

rs62149416

Intergenic

1.8 × 10−17

1.17 [NR]

European

(Tsoi et al. [2012])

REL

rs702873

Intron

4 × 10−9

1.12 [1.04 to 1.20]

European

(Strange et al. [2010])

NR

rs842636

Intron

6 × 10−6

1.15 [NR]

European

(Stuart et al. [2010])

2p15

B3GNT2

rs10865331

Intergenic

4.7 × 10−10

1.12 [NR]

European

(Tsoi et al. [2012])

5q33.3

PTTG1

rs2431697

Intergenic

1.11 × 10−8

1.20 [1.13 to 1.28]

Chinese

(Sun et al. [2010])

IL12B

rs12188300

Intergenic

3.2 × 10−53

1.58 [NR]

European

(Tsoi et al. [2012])

rs2546890

ncRNA

1 × 10−20

1.54 [1.32 to 1.79]

European

(Ellinghaus et al. [2010])

rs3213094

Intron

5 × 10−11

1.39 [1.26 to 1.53]

European

(Strange et al. [2010])

rs2082412

Intergenic

2 × 10−28

1.44 [NR]

European

(Nair et al. [2009])

rs3213094

Intron

3 × 10−26

1.28 [1.23 to 1.35]

Chinese

(Zhang et al. [2009])

rs2082412

Intergenic

4.75× 10−18

1.42 [NR]

European

(Elder [2009])

5q33.1

TNIP1/ANXA6

rs3762999

Intergenic

4.55 × 10−18

1.23 [1.18 to 1.29]

Chinese

(Sun et al. [2010])

rs999556

Intergenic

3.83 × 10−21

1.25 [1.20 to 1.31]

Chinese

TNIP1

rs17728338

Intergenic

1.4× 10−13

1.56 [NR]

European

(Elder [2009])

rs2233278

UTR-5

2.2 × 10−42

1.59 [NR]

European

(Tsoi et al. [2012])

rs17728338

Intergenic

1 × 10−20

1.59 [NR]

European

(Nair et al. [2009])

IL13, IL4

rs1295685

Intergenic

3.4 × 10−10

1.18 [NR]

European

(Tsoi et al. [2012])

IL13

rs20541

Missense

5 × 10−15

1.27 [NR]

European

(Nair et al. [2009])

5q15

ERAP1

rs27432

Intron

1.9 × 10−20

1.2 [NR]

European

(Tsoi et al. [2012])

rs27524

Intron

3 × 10−11

1.13 [1.05 to 1.22]

European

(Strange et al. [2010])

rs151823

Intergenic

9.32 × 10−9

0.89 [0.85 to 0.92]

Chinese

(Sun et al. [2010])

5q15

LNPEP

rs2303138

Missense

1.83 × 10−13

1.16 [NR]

Chinese

(Cheng et al. [2013])

6q25.4

EXOC2, IRF4

rs9504361

Intergenic

2.1 × 10−11

1.12 [NR]

European

(Tsoi et al. [2012])

6q25.3

TAGAP

rs2451258

Intergenic

3.4 × 10−8

1.12 [NR]

European

6q23.3

TNFAIP3

rs610604

Intron

3.07× 10−10

1.23 [NR]

European

(Elder [2009])

  

rs582757

Intron

2.2 × 10−25

1.23 [NR]

European

(Tsoi et al. [2012])

  

rs610604

Intron

9 × 10−12

1.19 [NR]

European

(Nair et al. [2009])

6q21

TRAF3IP2

rs33980500

Missense

4.2 × 10−45

1.52 [NR]

European

(Tsoi et al. [2012])

rs458017

Missense

2 × 10−16

1.37 [1.22 to 1.54]

European

(Strange et al. [2010])

rs13196377

Intron

1.39 × 10−12

1.67 [1.45 to 1.93]

European

(Huffmeier et al. [2010])

rs13190932

Intron

8.56 × 10−17

1.83 [1.59 to 2.12]

European

rs13210247

Missense

1.73 × 10−14

1.69 [1.48 to 1.94]

European

rs33980500

Missense

1 × 10−16

NR

European

(Ellinghaus et al. [2010])

rs240993

Intron

5 × 10−20

1.25 [1.16 to 1.34]

European

(Strange et al. [2010])

6p21.33

HLA-C

rs1265181

Intergenic

1.93 × 10−208

22.62 [NR]

Chinese

(Zhang et al. [2009])

rs12191877

Intergenic

2.98× 10−178

2.87 [NR]

European

(Elder [2009])

rs13191343

Intergenic

2.32 × 10−72

2.37 [2.16 to 2.61]

European

(Huffmeier et al. [2010])

rs12191877

Intergenic

4 × 10−32

2.79 [2.35 to 3.33]

European

(Ellinghaus et al. [2010])

rs10484554

Intergenic

4 × 10−214

4.66 [4.23 to 5.13]

European

(Strange et al. [2010])

rs12191877

Intergenic

1 × 10−100

2.64 [NR]

European

(Nair et al. [2009])

rs10484554

Intergenic

2 × 10−39

2.8 [2.40 to 3.30]

European

(Liu et al. [2008])

rs3134792

Intergenic

1 × 10−9

NR

European

(Capon et al. [2008])

HLA-B, HLA-C

rs4406273

Intergenic

4.5 × 10−723

4.32 [NR]

European

(Tsoi et al. [2012])

HCP5

rs2395029

ncRNA

2 × 10−26

4.1 [3.10 to 5.30]

European

(Liu et al. [2008])

7p14.1

ELMO1

rs2700987

Intron

4.3 × 10−9

1.11 [NR]

European

(Tsoi et al. [2012])

8p23.2

CSMD1

rs7007032

Intron

3.78 × 10−8

1.16 [1.10 to 1.22]

Chinese

(Sun et al. [2010])

rs10088247

Intron

4.54 × 10−9

1.17 [1.11 to 1.23]

Chinese

9q34.13

TSC1

rs1076160

Intron

6 × 10−6

1.09 [NR]

European

(Nair et al. [2009])

9q31.2

KLF4

rs10979182

Intergenic

2.3 × 10−8

1.12 [NR]

European

(Tsoi et al. [2012])

9p21.1

DDX58

rs11795343

Intron

8.4 × 10−11

1.11 [NR]

European

10q22.3

ZMIZ1

rs1250546

Intron

6.8 × 10−7

1.1 [NR]

European

11q24.3

ETS1

rs3802826

Intron

9.5 × 10−10

1.12 [NR]

European

ZC3H12C

rs4561177

nearGene-5

7.7 × 10−13

1.14 [NR]

European

11q13.1

RPS6KA4, PRDX5

rs645078

Intergenic

2.2 × 10−6

1.09 [NR]

European

12q13.3

STAT2, IL23A

rs2066819

Intergenic

5.4 × 10−17

1.39 [NR]

European

IL23A, STAT2

rs2066808

Intron

1 × 10−9

1.34 [NR]

European

(Nair et al. [2009])

IL23A

rs2066807

Missense

1.9× 10−5

1.33 [NR]

European

(Elder [2009])

rs2066808

Intron

2 × 10−7

1.49 [1.28 to 1.73]

European

(Strange et al. [2010])

12q13.2

RPS26

rs12580100

Intergenic

1 × 10−6

1.17 [NR]

European

(Stuart et al. [2010])

13q14.11

COG6

rs7993214

Intron

2 × 10−6

1.41 [1.22 to 1.61]

European

(Liu et al. [2008])

GJB2

rs3751385

UTR-3

8.57 × 10−8

0.87 [0.84 to 0.91]

Chinese

(Sun et al. [2010])

14q13.2

NFKBIA, PSMA6

rs12586317

Intron

2 × 10−8

1.15 [NR]

European

(Stuart et al. [2010])

NFKBIA

rs8016947

Intergenic

2 × 10−11

1.19 [1.11 to 1.27]

European

(Strange et al. [2010])

3.9 × 10−10

1.12 [NR]

Chinese

(Li et al. [2013])

16p13.13

PRM3, SOCS1

rs367569

Intergenic

4.9 × 10−8

1.13 [NR]

European

(Tsoi et al. [2012])

16p11.2

PRSS53, FBXL19

rs12445568

Intergenic

1.2 × 10−16

1.16 [NR]

European

FBXL19, POL3S

rs10782001

Intron

9 × 10−10

1.16 [NR]

European

(Stuart et al. [2010])

17q25.3

CARD14

rs11652075

Missense

3.4 × 10−8

1.11 [NR]

European

(Tsoi et al. [2012])

17q21.2

PTRF, STAT3, STAT5A/B

rs963986

Intergenic

5.3 × 10−9

1.15 [NR]

European

17q11.2

NOS2

rs28998802

Intron

3.3 × 10−16

1.22 [NR]

European

rs4795067

Intron

4 × 10−11

1.19 [NR]

European

(Stuart et al. [2010])

NR

rs1975974

Intergenic

1 × 10-7

1.17 [NR]

European

18q22.1

SERPINB8

rs514315

nearGene-3

5.92 × 10−9

0.87 [0.83 to 0.91]

Chinese

(Sun et al. [2010])

18q21.2

POL1, STARD6, MBD2

rs545979

Intergenic

3.5 × 10−10

1.12 [NR]

European

(Tsoi et al. [2012])

19q13.41

ZNF816A

rs9304742

Intron

2.11 × 10−9

0.88 [0.84 to 0.92]

Chinese

(Sun et al. [2010])

19p13.2

ILF3, CARM1

rs892085

Intergenic

3.0 × 10−17

1.17 [NR]

European

(Tsoi et al. [2012])

TYK2

rs34536443

Missense

9.1 × 10−31

1.88 [NR]

European

rs12720356

Missense

4 × 10−11

1.4 [1.23 to 1.61]

European

(Strange et al. [2010])

rs280519

Intron

4 × 10−9

1.13 [1.05 to 1.21]

European

20q13.13

ZNF313

rs2235617

Intron

2 × 10−6

1.2 [1.11 to 1.30]

European

RNF114

rs1056198

Intron

1.5 × 10−14

1.16 [NR]

European

(Tsoi et al. [2012])

ZNF313

rs495337

Cds-synon

1 × 10−8

1.25 [1.12 to 1.39]

European

(Capon et al. [2008])

20q13.12

SDC4

rs1008953

Intergenic

1 × 10−7

1.14 [NR]

European

(Stuart et al. [2010])

22q11.21

UBE2L3

rs4821124

Intron

3.8 × 10−8

1.13 [NR]

European

(Tsoi et al. [2012])

  1. NR, not reported; UTR, untranslated region; ncRNA, noncoding RNA; nearGene-5/3, a SNP close to the 5′ or 3′ end of a gene. Intergenic: a stretch of sequences located between genes.