Table 3 Susceptibility genes in risk loci shared by autoimmune or inflammatory diseases
Region | Reported gene(s) | Biological annotations | Autoimmune and inflammatory diseases overlap |
|---|---|---|---|
1p31.3 | IL23R | IL-23/Th17 axis | PsV, AS, BD, CD, LE, UC |
1p36.11 | RUNX3 | CD8+ T lymphocyte differentiation | PsV, CD, AS, CeD |
2q24.2 | IFIH1 | Interferon signaling pathway | PsV, T1D, vitiligo |
2p16.1 | REL | Rel/NF-κB family | PsV, PA, CD, RA, CeD, IBD |
5q33.3 | IL12B | Th1 cell differentiation | PsV, CD, IBD, MS, PA, UC, |
5q33.1 | TNIP1 | NF-κB pathway | PsV, IBD, SS, SLE, myasthenia gravis |
5q31.1 | IL13 | Th2 cell differentiation | PsV, IBD, asthma, AD |
5q15 | ERAP1 | MHC class I processing | PsV, AS, BD |
6q23.3 | TNFAIP3 | NF-κB pathway | PsV, CeD, SLE, IBD, RA |
6q21 | TRAF3IP2 | NF-κB pathway; IL-23/Th17 axis | PsV, IBD, PA |
6p21.33 | HLA-C | MHC class I processing | PsV, CD, PA, CRD, SJS-TEN, vitiligo |
10q22.3 | ZMIZ1 | Inhibitor of activated STAT | PsV, MS, CD, vitiligo, CeD, IBD, |
11q24.3 | ETS1 | Regulation of Th17 and B cells | PsV, SLE, CD, RA |
16p13.13 | SOCS1 | IL-7RA/IL-7 pathway | PsV, MS, T1D |
19p13.2 | TYK2 | IL-23/Th17 signaling | PsV, MS, T1D, CD |
22q11.21 | UBE2L3 | Ubiquitin-conjugating enzyme | PsV, SLE, IBD, CeD, RA |