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Table 3 Susceptibility genes in risk loci shared by autoimmune or inflammatory diseases

From: The immunological and genetic aspects in psoriasis

Region Reported gene(s) Biological annotations Autoimmune and inflammatory diseases overlap
1p31.3 IL23R IL-23/Th17 axis PsV, AS, BD, CD, LE, UC
1p36.11 RUNX3 CD8+ T lymphocyte differentiation PsV, CD, AS, CeD
2q24.2 IFIH1 Interferon signaling pathway PsV, T1D, vitiligo
2p16.1 REL Rel/NF-κB family PsV, PA, CD, RA, CeD, IBD
5q33.3 IL12B Th1 cell differentiation PsV, CD, IBD, MS, PA, UC,
5q33.1 TNIP1 NF-κB pathway PsV, IBD, SS, SLE, myasthenia gravis
5q31.1 IL13 Th2 cell differentiation PsV, IBD, asthma, AD
5q15 ERAP1 MHC class I processing PsV, AS, BD
6q23.3 TNFAIP3 NF-κB pathway PsV, CeD, SLE, IBD, RA
6q21 TRAF3IP2 NF-κB pathway; IL-23/Th17 axis PsV, IBD, PA
6p21.33 HLA-C MHC class I processing PsV, CD, PA, CRD, SJS-TEN, vitiligo
10q22.3 ZMIZ1 Inhibitor of activated STAT PsV, MS, CD, vitiligo, CeD, IBD,
11q24.3 ETS1 Regulation of Th17 and B cells PsV, SLE, CD, RA
16p13.13 SOCS1 IL-7RA/IL-7 pathway PsV, MS, T1D
19p13.2 TYK2 IL-23/Th17 signaling PsV, MS, T1D, CD
22q11.21 UBE2L3 Ubiquitin-conjugating enzyme PsV, SLE, IBD, CeD, RA
  1. (Using NHGR1 GWAS catalog data, http://www.genome.gov/gwastudies/). PsV, psoriasis vulgaris; PsA, psoriatic arthritis; AD, atopic dermatitis; IBD, inflammatory bowel disease; AS, ankylosing spondylitis; BD, Behcet's disease; CD, Crohn's disease; CeD, celiac disease; LE, leprosy; MS, multiple sclerosis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, systemic sclerosis; T1D, type I diabetes; UC, ulcerative colitis; SJS-TEN, Stevens-Johnson syndrome and toxic epidermal necrolysis.