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Table 1 Blood pressure/hypertension loci reported by genome-wide association studies and candidate gene studies

From: An update on genome-wide association studies of hypertension

Chr Genes Lead SNP Position Trait Ethnicity
1p36.22 CASZ1 rs880315 10,736,809 SBP EA( Levy et al. 2009) Asian (Takeuchi et al. 2010) EA (Ho et al. 2011) Asian (Kato et al. 2011) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
1p36.22 MTHFR-NPPB rs17367504 11,802,721 SBP EA (Newton-Cheh et al. 2009) EA (Tomaszewski et al. 2010) Asian (Takeuchi et al. 2010) EA (Johnson et al. 2011b) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) EA (Ganesh et al. 2013) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
1p13.2 ST7L-MOV10 rs2932538 112,673,921 SBP DBP EA (ICBP 2011) Asian (Kato et al. 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
1q32.1 MDM4 rs2169137 204,528,785 DBP EA (Ganesh et al. 2013) EA (Tragante et al. 2014)
1q42.2 AGT rs2004776 230,712,956 HT EA (Johnson et al. 2011b) EA (Johnson et al. 2011a) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
2p23.2 KCNK3 rs1275988 26,691,496 SBP MAP EA (Ganesh et al. 2014)
2q11.2 FER1L5 rs7599598 96,686,103 DBP EA (Ganesh et al. 2014)
2q24.3 FIGN rs13002573 164,058,698 PP MAP EA (Wain et al. 2011) Asian (Kato et al. 2011) Asian (Hong et al. 2012) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
2q24.3 STK39 rs6749447 168,184,876 SBP EA (Wang et al. 2009) AA (Adeyemo et al. 2009) EA (Tragante et al. 2014)
2q32.1 PDE1A rs16823124 182,359,400 DBP MAP EA (Tragante et al. 2014)
2q32.2 PMS1 rs5743185 189,873,112 SBP AA (Adeyemo et al. 2009) EA (Levy et al. 2009)
3p25.3 HRH1 rs347591 11,248,436 SBP EA (Ganesh et al. 2013) EA (Tragante et al. 2014)
3p24.1 SLC4A7 rs13082711 27,496,418 DBP EA (ICBP 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
3p22.1 ULK4 rs9815354 41,871,159 DBP EA (Levy et al. 2009) EA (ICBP 2011) EA + AA + Asian (Franceschini et al. 2013) Asian (Lu et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
3p21.31 MAP4 rs319690 47,885,994 MAP EA (Wain et al. 2011) Asian (Hong et al. 2012) Asian (Kelly et al. 2013) EA (Simino et al. 2014) EA (Tragante et al. 2014)
3p21.1 CACNA1D rs9810888 53,601,568 DBP Asian (Lu et al. 2014)
3q26.1 MIR1263 rs16833934 164,019,462 DBP EA (Simino et al. 2014)
3q26.2 MECOM rs419076 169,383,098 SBP DBP EA (ICBP 2011) EA (Tragante et al. 2014)
4q12 CHIC2 rs871606 53,933,078 PP EA (Wain et al. 2011) Asian (Hong et al. 2012) EA (Tragante et al. 2014)
4q21.21 FGF5 rs16998073 80,263,187 DBP EA (Newton-Cheh et al. 2009) Asian (Takeuchi et al. 2010) Asian (Tabara et al. 2010) Asian (Kato et al. 2011) EA (ICBP 2011) Asian (Kelly et al. 2013) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Tragante et al. 2014)
4q24 SLC39A8 rs13107325 102,267,552 SBP DBP EA (ICBP 2011) EA (Tragante et al. 2014)
4q25 ENPEP rs6825911 110,460,482 DBP Asian (Kato et al. 2011) EA (Tragante et al. 2014)
4q32.1 GUCY1A3-GUCY1B3 rs13139571 155,724,361 DBP EA (ICBP 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
5p13.3 NPR3-C5orf23 rs1173771 32,814,922 SBP DBP HT EA (ICBP 2011) AA (Zhu et al. 2011) EA (Johnson et al. 2011b) Asian (Kato et al. 2011) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
5q33.3 EBF1 rs11953630 158,418,394 SBP DBP EA (ICBP 2011) EA (Simino et al. 2014) EA (Tragante et al. 2014)
6p22.2 HFE rs1799945 26,090,951 SBP DBP HT EA (ICBP 2011) EA (Johnson et al. 2011b) EA (Ganesh et al. 2013) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
6p21.33 BAT2-CYP21A2 rs805303 31,648,589 SBP DBP HT EA (ICBP 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
6p21.32 HLA-DQB1 rs2854275 32,660,651 DBP EA (Tragante et al. 2014)
6p21.1 CRIP3 rs10948071 43,312,975 PP EA (Ganesh et al. 2014)
6q22.33 RSPO3 rs13209747 126,794,309 SBP DBP EA + AA + Asian (Franceschini et al. 2013)
6q25.1 PLEKHG1 rs17080102 150,683,634 SBP DBP EA + AA + Asian (Franceschini et al. 2013)
7p15.2 EVX1-HOXA rs17428471 27,298,248 SBP DBP EA + AA + Asian (Franceschini et al. 2013)
7p12.3 IGFBP3 rs2949837 45,954,779 PP EA (Ganesh et al. 2014)
7q21.2 CDK6 rs2282978 92,635,096 PP EA (Tragante et al. 2014)
7q22.3 PIK3CG rs17477177 106,771,412 PP EA (Wain et al. 2011) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
7q36.1 NOS3 rs3918226 150,993,088 DBP EA (Johnson et al. 2011b) EA (Salvi et al. 2012) EA (Tragante et al. 2014)
8p23.1 BLK-GATA4 rs4841569 11,594,668 SBP MAP EA (Simino et al. 2014) EA (Tragante et al. 2014)
8q24.12 NOV rs2071518 119,423,572 PP EA (Wain et al. 2011) EA (Tragante et al. 2014)
10p12.31 CACNB2 rs11014166 18,419,869 DBP EA (Levy et al. 2009) EA (Ho et al. 2011) EA (ICBP 2011) Asian (Lin et al. 2011) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
10q21.2 c10orf107 rs1530440 61,764,833 DBP EA (Newton-Cheh et al. 2009) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
10q22.2 VCL rs4746172 74,096,084 DBP MAP EA (Tragante et al. 2014)
10q23.33 PLCE1 rs932764 94,136,183 SBP HT EA (ICBP 2011) EA (Tragante et al. 2014)
10q24.32 CYP17A1-NT5C2 rs1004467 102,834,750 SBP EA (Levy et al. 2009) EA (Newton-Cheh et al. 2009) Asian (Takeuchi et al. 2010) Asian (Hong et al. 2010) Asian (Tabara et al. 2010) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) Asian (Lin et al. 2011) Asian (Kelly et al. 2013) EA (Ganesh et al. 2013) Asian (Lu et al. 2014) Asian (Qi et al. 2014) EA (Simino et al. 2014) EA (Tragante et al. 2014)
10q25.3 ADRB1 rs2782980 114,021,768 MAP EA (Wain et al. 2011) EA (Ganesh et al. 2013) EA (Simino et al. 2014) EA (Tragante et al. 2014)
11p15.5 LSP1 rs661348 1,884,062 MAP EA (Johnson et al. 2011b) EA (Ganesh et al. 2013) EA (Tragante et al. 2014)
11p15.4 ADM rs7129220 10,328,991 SBP EA (ICBP 2011) EA (Tragante et al. 2014)
11p15.1 PLEKHA7 rs381815 16,880,721 SBP EA (Levy et al. 2009) Asian (Hong et al. 2010) EA (Ho et al. 2011) EA (ICBP 2011) EA (Johnson et al. 2011b) Asian (Lin et al. 2011) EA + AA + Asian (Franceschini et al. 2013) EA (Ganesh et al. 2013) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Tragante et al. 2014)
11q13.1 EHBP1L1 rs4601790 65,586,435 MAP DBP EA (Simino et al. 2014) EA (Tragante et al. 2014)
11q22.1 FLJ32810-TMEM133 rs633185 100,722,807 SBP DBP HT EA (ICBP 2011) EA (Tragante et al. 2014)
11q24.3 ADAMTS8 rs11222084 130,403,335 PP EA (Wain et al. 2011) EA (Tragante et al. 2014)
12q13.13 HOXC4 rs7297416 54,049,306 SBP EA (Tragante et al. 2014)
12q21.33 ATP2B1 rs2681492 89,619,312 SBP DBP HT EA (Levy et al. 2009) Asian (Cho et al. 2009) Asian (Takeuchi et al. 2010) Asian (Hong et al. 2010) Asian (Tabara et al. 2010) EA (Johnson et al. 2011b) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) Asian (Wang et al. 2013b) Asian (Kelly et al. 2013) EA (Ganesh et al. 2013) Asian (Lu et al. 2014) Asian (Qi et al. 2014) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
12q24.12 SH2B3 rs3184504 111,446,804 SBP DBP EA (Levy et al. 2009) EA (Newton-Cheh et al. 2009) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) AA (Fox et al. 2011) EA (Ganesh et al. 2013) Asian (Lu et al. 2014) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
12q24.13 ALDH2 rs11066280 112,379,979 SBP DBP Asian (Kato et al. 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
12q24.21 TBX3-TBX5 rs2384550 114,914,926 DBP EA (Levy et al. 2009) Asian (Kato et al. 2011) EA (ICBP 2011) AA (Fox et al. 2011) Asian (Lu et al. 2014) Asian (Qi et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
12q24.21 MED13L rs11067763 115,760,536 SBP DBP Asian (Lu et al. 2014)
15q21.1 FBN1 rs1036477 48,622,729 PP EA (Tragante et al. 2014)
15q24.1 CYP1A1-ULK3 rs6495122 74,833,304 DBP EA (Levy et al. 2009) EA (Newton-Cheh et al. 2009) Asian (Takeuchi et al. 2010) Asian (Hong et al. 2010) Asian (Tabara et al. 2010) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) AA (Fox et al. 2011) EA (Ganesh et al. 2013) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
15q26.1 FURIN-FES rs2521501 90,894,158 SBP DBP EA (ICBP 2011) EA (Ganesh et al. 2013) EA (Tragante et al. 2014)
16p12.3 UMOD rs13333226 20,354,332 HT EA (Padmanabhan et al. 2010) EA (Tragante et al. 2014)
16q22.1 NFAT5 rs33063 69,606,314 PP EA (Tragante et al. 2014)
16q23.3 CDH13 rs11646213 82,609,046 HT EA (Org et al. 2009) AA (Adeyemo et al. 2009) EA (Tragante et al. 2014)
17q21.32 GOSR2 rs17608766 46,935,905 SBP EA (ICBP 2011) EA (Simino et al. 2014) EA (Tragante et al. 2014)
17q21.33 ZNF652 rs16948048 49,363,104 DBP EA (Newton-Cheh et al. 2009) EA (Ho et al. 2011) Asian (Kato et al. 2011) EA (ICBP 2011) EA (Tragante et al. 2014)
20p12.2 JAG1 rs1327235 10,988,382 SBP DBP EA (ICBP 2011) Asian (Lu et al. 2014) EA (Tragante et al. 2014)
20q13.32 GNAS-EDN3 rs6015450 59,176,062 SBP DBP HT EA (ICBP 2011) EA (Simino et al. 2014) EA (Ganesh et al. 2014) EA (Tragante et al. 2014)
  1. Lead SNP and trait are as reported in the first reference for each locus listed in the table. Position is based on dbSNP 142/hg38
  2. Chr Chromosomal region, AA African Ancestry, EA European Ancestry, HT Hypertension