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Applied Informatics

Table 1 Blood pressure/hypertension loci reported by genome-wide association studies and candidate gene studies

From: An update on genome-wide association studies of hypertension

Chr

Genes

Lead SNP

Position

Trait

Ethnicity

1p36.22

CASZ1

rs880315

10,736,809

SBP

EA( Levy et al. 2009)

Asian (Takeuchi et al. 2010)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

1p36.22

MTHFR-NPPB

rs17367504

11,802,721

SBP

EA (Newton-Cheh et al. 2009)

EA (Tomaszewski et al. 2010)

Asian (Takeuchi et al. 2010)

EA (Johnson et al. 2011b)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

EA (Ganesh et al. 2013)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

1p13.2

ST7L-MOV10

rs2932538

112,673,921

SBP

DBP

EA (ICBP 2011)

Asian (Kato et al. 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

1q32.1

MDM4

rs2169137

204,528,785

DBP

EA (Ganesh et al. 2013)

EA (Tragante et al. 2014)

1q42.2

AGT

rs2004776

230,712,956

HT

EA (Johnson et al. 2011b)

EA (Johnson et al. 2011a)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

2p23.2

KCNK3

rs1275988

26,691,496

SBP

MAP

EA (Ganesh et al. 2014)

2q11.2

FER1L5

rs7599598

96,686,103

DBP

EA (Ganesh et al. 2014)

2q24.3

FIGN

rs13002573

164,058,698

PP

MAP

EA (Wain et al. 2011)

Asian (Kato et al. 2011)

Asian (Hong et al. 2012)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

2q24.3

STK39

rs6749447

168,184,876

SBP

EA (Wang et al. 2009)

AA (Adeyemo et al. 2009)

EA (Tragante et al. 2014)

2q32.1

PDE1A

rs16823124

182,359,400

DBP

MAP

EA (Tragante et al. 2014)

2q32.2

PMS1

rs5743185

189,873,112

SBP

AA (Adeyemo et al. 2009)

EA (Levy et al. 2009)

3p25.3

HRH1

rs347591

11,248,436

SBP

EA (Ganesh et al. 2013)

EA (Tragante et al. 2014)

3p24.1

SLC4A7

rs13082711

27,496,418

DBP

EA (ICBP 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

3p22.1

ULK4

rs9815354

41,871,159

DBP

EA (Levy et al. 2009)

EA (ICBP 2011)

EA + AA + Asian (Franceschini et al. 2013)

Asian (Lu et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

3p21.31

MAP4

rs319690

47,885,994

MAP

EA (Wain et al. 2011)

Asian (Hong et al. 2012)

Asian (Kelly et al. 2013)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

3p21.1

CACNA1D

rs9810888

53,601,568

DBP

Asian (Lu et al. 2014)

3q26.1

MIR1263

rs16833934

164,019,462

DBP

EA (Simino et al. 2014)

3q26.2

MECOM

rs419076

169,383,098

SBP

DBP

EA (ICBP 2011)

EA (Tragante et al. 2014)

4q12

CHIC2

rs871606

53,933,078

PP

EA (Wain et al. 2011)

Asian (Hong et al. 2012)

EA (Tragante et al. 2014)

4q21.21

FGF5

rs16998073

80,263,187

DBP

EA (Newton-Cheh et al. 2009)

Asian (Takeuchi et al. 2010)

Asian (Tabara et al. 2010)

Asian (Kato et al. 2011)

EA (ICBP 2011)

Asian (Kelly et al. 2013)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

4q24

SLC39A8

rs13107325

102,267,552

SBP

DBP

EA (ICBP 2011)

EA (Tragante et al. 2014)

4q25

ENPEP

rs6825911

110,460,482

DBP

Asian (Kato et al. 2011)

EA (Tragante et al. 2014)

4q32.1

GUCY1A3-GUCY1B3

rs13139571

155,724,361

DBP

EA (ICBP 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

5p13.3

NPR3-C5orf23

rs1173771

32,814,922

SBP

DBP

HT

EA (ICBP 2011)

AA (Zhu et al. 2011)

EA (Johnson et al. 2011b)

Asian (Kato et al. 2011)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

5q33.3

EBF1

rs11953630

158,418,394

SBP

DBP

EA (ICBP 2011)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

6p22.2

HFE

rs1799945

26,090,951

SBP

DBP

HT

EA (ICBP 2011)

EA (Johnson et al. 2011b)

EA (Ganesh et al. 2013)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

6p21.33

BAT2-CYP21A2

rs805303

31,648,589

SBP

DBP

HT

EA (ICBP 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

6p21.32

HLA-DQB1

rs2854275

32,660,651

DBP

EA (Tragante et al. 2014)

6p21.1

CRIP3

rs10948071

43,312,975

PP

EA (Ganesh et al. 2014)

6q22.33

RSPO3

rs13209747

126,794,309

SBP

DBP

EA + AA + Asian (Franceschini et al. 2013)

6q25.1

PLEKHG1

rs17080102

150,683,634

SBP

DBP

EA + AA + Asian (Franceschini et al. 2013)

7p15.2

EVX1-HOXA

rs17428471

27,298,248

SBP

DBP

EA + AA + Asian (Franceschini et al. 2013)

7p12.3

IGFBP3

rs2949837

45,954,779

PP

EA (Ganesh et al. 2014)

7q21.2

CDK6

rs2282978

92,635,096

PP

EA (Tragante et al. 2014)

7q22.3

PIK3CG

rs17477177

106,771,412

PP

EA (Wain et al. 2011)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

7q36.1

NOS3

rs3918226

150,993,088

DBP

EA (Johnson et al. 2011b)

EA (Salvi et al. 2012)

EA (Tragante et al. 2014)

8p23.1

BLK-GATA4

rs4841569

11,594,668

SBP

MAP

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

8q24.12

NOV

rs2071518

119,423,572

PP

EA (Wain et al. 2011)

EA (Tragante et al. 2014)

10p12.31

CACNB2

rs11014166

18,419,869

DBP

EA (Levy et al. 2009)

EA (Ho et al. 2011)

EA (ICBP 2011)

Asian (Lin et al. 2011)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

10q21.2

c10orf107

rs1530440

61,764,833

DBP

EA (Newton-Cheh et al. 2009)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

10q22.2

VCL

rs4746172

74,096,084

DBP

MAP

EA (Tragante et al. 2014)

10q23.33

PLCE1

rs932764

94,136,183

SBP

HT

EA (ICBP 2011)

EA (Tragante et al. 2014)

10q24.32

CYP17A1-NT5C2

rs1004467

102,834,750

SBP

EA (Levy et al. 2009)

EA (Newton-Cheh et al. 2009)

Asian (Takeuchi et al. 2010)

Asian (Hong et al. 2010)

Asian (Tabara et al. 2010)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

Asian (Lin et al. 2011)

Asian (Kelly et al. 2013)

EA (Ganesh et al. 2013)

Asian (Lu et al. 2014)

Asian (Qi et al. 2014)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

10q25.3

ADRB1

rs2782980

114,021,768

MAP

EA (Wain et al. 2011)

EA (Ganesh et al. 2013)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

11p15.5

LSP1

rs661348

1,884,062

MAP

EA (Johnson et al. 2011b)

EA (Ganesh et al. 2013)

EA (Tragante et al. 2014)

11p15.4

ADM

rs7129220

10,328,991

SBP

EA (ICBP 2011)

EA (Tragante et al. 2014)

11p15.1

PLEKHA7

rs381815

16,880,721

SBP

EA (Levy et al. 2009)

Asian (Hong et al. 2010)

EA (Ho et al. 2011)

EA (ICBP 2011)

EA (Johnson et al. 2011b)

Asian (Lin et al. 2011)

EA + AA + Asian (Franceschini et al. 2013)

EA (Ganesh et al. 2013)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

11q13.1

EHBP1L1

rs4601790

65,586,435

MAP

DBP

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

11q22.1

FLJ32810-TMEM133

rs633185

100,722,807

SBP

DBP

HT

EA (ICBP 2011)

EA (Tragante et al. 2014)

11q24.3

ADAMTS8

rs11222084

130,403,335

PP

EA (Wain et al. 2011)

EA (Tragante et al. 2014)

12q13.13

HOXC4

rs7297416

54,049,306

SBP

EA (Tragante et al. 2014)

12q21.33

ATP2B1

rs2681492

89,619,312

SBP

DBP

HT

EA (Levy et al. 2009)

Asian (Cho et al. 2009)

Asian (Takeuchi et al. 2010)

Asian (Hong et al. 2010)

Asian (Tabara et al. 2010)

EA (Johnson et al. 2011b)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

Asian (Wang et al. 2013b)

Asian (Kelly et al. 2013)

EA (Ganesh et al. 2013)

Asian (Lu et al. 2014)

Asian (Qi et al. 2014)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

12q24.12

SH2B3

rs3184504

111,446,804

SBP

DBP

EA (Levy et al. 2009)

EA (Newton-Cheh et al. 2009)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

AA (Fox et al. 2011)

EA (Ganesh et al. 2013)

Asian (Lu et al. 2014)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

12q24.13

ALDH2

rs11066280

112,379,979

SBP

DBP

Asian (Kato et al. 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

12q24.21

TBX3-TBX5

rs2384550

114,914,926

DBP

EA (Levy et al. 2009)

Asian (Kato et al. 2011)

EA (ICBP 2011)

AA (Fox et al. 2011)

Asian (Lu et al. 2014)

Asian (Qi et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

12q24.21

MED13L

rs11067763

115,760,536

SBP

DBP

Asian (Lu et al. 2014)

15q21.1

FBN1

rs1036477

48,622,729

PP

EA (Tragante et al. 2014)

15q24.1

CYP1A1-ULK3

rs6495122

74,833,304

DBP

EA (Levy et al. 2009)

EA (Newton-Cheh et al. 2009)

Asian (Takeuchi et al. 2010)

Asian (Hong et al. 2010)

Asian (Tabara et al. 2010)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

AA (Fox et al. 2011)

EA (Ganesh et al. 2013)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

15q26.1

FURIN-FES

rs2521501

90,894,158

SBP

DBP

EA (ICBP 2011)

EA (Ganesh et al. 2013)

EA (Tragante et al. 2014)

16p12.3

UMOD

rs13333226

20,354,332

HT

EA (Padmanabhan et al. 2010)

EA (Tragante et al. 2014)

16q22.1

NFAT5

rs33063

69,606,314

PP

EA (Tragante et al. 2014)

16q23.3

CDH13

rs11646213

82,609,046

HT

EA (Org et al. 2009)

AA (Adeyemo et al. 2009)

EA (Tragante et al. 2014)

17q21.32

GOSR2

rs17608766

46,935,905

SBP

EA (ICBP 2011)

EA (Simino et al. 2014)

EA (Tragante et al. 2014)

17q21.33

ZNF652

rs16948048

49,363,104

DBP

EA (Newton-Cheh et al. 2009)

EA (Ho et al. 2011)

Asian (Kato et al. 2011)

EA (ICBP 2011)

EA (Tragante et al. 2014)

20p12.2

JAG1

rs1327235

10,988,382

SBP

DBP

EA (ICBP 2011)

Asian (Lu et al. 2014)

EA (Tragante et al. 2014)

20q13.32

GNAS-EDN3

rs6015450

59,176,062

SBP

DBP

HT

EA (ICBP 2011)

EA (Simino et al. 2014)

EA (Ganesh et al. 2014)

EA (Tragante et al. 2014)

  1. Lead SNP and trait are as reported in the first reference for each locus listed in the table. Position is based on dbSNP 142/hg38
  2. Chr Chromosomal region, AA African Ancestry, EA European Ancestry, HT Hypertension
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